Research Scientist Lead Evaluation

Profile

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Description: This position in Leads Discovery and Optimization will be responsible for developing and performing cell-based assays for lead optimization support of multiple drug discovery programs. The candidate will develop protocols, perform assays, analyze data and have responsibility for effectively communicating assay results. The candidate should have strong assay development skills and working knowledge of cell biology and cellular signaling with excellent skills in cell culture techniques, including experience working with whole blood, handling and isolating primary cells and ex vivo samples for assay execution. The candidate must display highly detail-oriented laboratory skills in bioassay techniques for cellular-based assays. Multiparameter high content image analysis and multi-color flow cytometry expertise is desired. Experience with automated liquid handlers, plate readers, automation software and robotics is preferred. Expertise in computer skills, databases, data analytics and specialized analysis tools is required. The candidate will be self-motivating, have excellent interpersonal and communication skills, be able to multi-task, be highly organized, and have the proven ability to work in a multifunctional team setting.

Duties/Responsibilities:


Collaborate with colleagues across R&D to develop high-quality cell-based assays and adapt protocols for miniaturization and high-throughput screening.
Execute routine cell-based screening assays to ensure rapid and high quality data delivery.
Troubleshoot assays to ensure high data quality.
Interface closely with disease biology & translational research colleagues to ensure assays and screening efforts are well-aligned to the scientific project goals and to ensure follow-through on well-defined lead optimization plans.
Lead efforts to identify, evaluate, and implement new technologies and methods that push the boundaries of complex cell-based screening.
Interface with Informatics and Automation colleagues to proactively drive the evolution of screening platforms and ensure adequate maintenance of the cell-based assay infrastructure.
Analyze, interpret and effectively present data at team meetings.


Qualifications


BS or Master's degree in biochemistry, pharmacology, cell biology, immunology or related field, with at least 3-5 years relevant research experience in an industry laboratory.
Demonstrated hands-on experience in developing a range of high-throughput, functional cell-based signaling assays in recombinant and primary cells.
Practical expertise with high throughput screening using automated platforms and processes in a lead optimization environment. Flow cytometry expertise is strongly desired. High content screening experience is a plus.
Candidate must be highly motivated, highly organized and possess excellent verbal and written communication skills and data analysis skills.
The ability to work effectively in a matrixed, team-oriented environment is essential.
Ability and desire to master new skills, methods and technologies in a technology-enabled environment is very important.


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Company: Bristol-Myers Squibb

Req Number: R1527090_EN

Updated: 2020-07-08 00:00:00.000 UTC

Location: Princeton,New Jersey

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

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