: In Vivo Pharmacology Associate Research Scientist

Profile

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

The In Vivo Pharmacology Associate Research Scientist will join the Oncology Discovery Pharmacology and In Vivo Biology group at Bristol-Myers Squibb in Cambridge, MA. The individual hired for this position will conduct experiments utilizing syngeneic and xenograft mouse or rat models to aide in the advancement of early stage therapeutics targeting pathways required for tumor proliferation and survival.

The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment to advance preclinical drug development programs from target identification/validation through IND enabling activities.

Qualifications


A B.S. with a minimum of 2 years relevant industry or comparable academic experience leveraging in vivo pharmacology models to explore cancer biology and enable drug discovery is required.

Demonstrated experience independently running and analyzing data from in vivo xenograft or syngeneic tumor efficacy and PK/PD studies is required.

Required skills include: tumor model development, dosing (IV, IP, SC, I-TUMOR and PO routes), tumor measurements by caliper, blood collection and tissue/tumor collection at necropsy

Experience with monitoring solid tumor growth in mouse models using ultrasound is highly desired but not required.

Surgical experience with orthotopic tumor implantations in mice is a plus.

Proficiency in cell culture is required.

Experience with ex vivo techniques such as qPCR, ELISA (MSD), or WB is highly desired.

Proficiency in utilizing software such as Graph Pad, Microsoft office etc. for data analysis and figure generation is required.

Ability to mentor junior scientists and colleagues on best practices in the laboratory would be highly valued.

Attention to detail with excellent organizational and record keeping skills is a requirement.


Responsibilities include:


Independently conduct and analyze xenograft and syngeneic in vivo studies including anti-tumor efficacy and PK/PD studies

Contribute to the utilization of ELISAs (MSD), qPCR, or WB to monitor biomarkers in harvested tissues

Accurately maintain proper scientific documentation of experiments and associated data in an electronic lab notebook.

Effectively communicate and present summaries of research results to team members.

This position is located in Cambridge, MA.


Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Bristol-Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

Company info

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