Scientist Delivery and Editing Technology - Cell Therapy

Profile

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Cell Therapy Process Sciences and Technology team is seeking an individual to join its innovative, multi-disciplinary team focusing on non-viral, formulation-based gene delivery technologies. As a member of the Delivery and Editing Technology team, the individual will support the advancement of the T-cell engineering technologies for manufacturing immune-therapeutic products. This role will provide a challenging but rewarding opportunity for career development. A successful candidate is required to be well-versed in lipid/polymer-based formulation and screening, and aware of the limitations in ex-vivo and in-vivo applications.

Education and Experiences


PhD in Bioengineering, Chemical Engineering, Chemistry, Materials Science, or related discipline with 2 years of relevant postdoctoral or industrial experience


Expertise and Skills


Strong expertise in non-viral nucleic acid delivery using at least one of the following drug delivery systems: lipid nanoparticles (LNPs), synthetic polymer-based drug delivery systems, polymer and/or lipid transfection reagents, nanoparticle functionalization and targeting
Deep understanding of cellular uptake mechanisms related to non-viral nucleic acid delivery
Extensive experience with transfection of mammalian cells; experience with primary cell types (PBMCs, T cells, stem cells, etc.) is a plus
Knowledge of gene integration technologies (transposons, gene editing via homology-directed repair, etc)
Familiarity with flow cytometry analysis
Familiarity with statistical design of experiments (DoE)


Duties and Responsibilities


Managing research project
Executing experimental plans
Data-driven decision making and troubleshooting
Strategic planning with alignment to higher level goals
Coaching junior members
CRO/CMO and vendor management
Cross-functional communications and collaborations


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Company: Bristol-Myers Squibb

Req Number: R1527671_EN

Updated: 2020-07-20 00:00:00.000 UTC

Location: Seattle,Washington

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

Company info

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