Principal Scientist CAR/TCR Biology

Profile

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

The Preclinical CAR T and TCR Biology team is seeking an experienced and driven immunologist with a strong background in T cell biology to advance anti-tumor cell therapies by leading efforts for optimization of CAR T and TCR engineered therapeutics. The successful candidate will have experience in tumor-associated T cell immunology, supervisory experience and a passion for T cell therapy research. Working in lead optimization of T cell therapeutics, this position is ideal for the scientist who is interested in continually learning new technologies to incorporate into CAR/TCR engineered T cell therapeutics in a fast-paced, collaborative and innovative environment.

Responsibilities include but are not limited to:


Application of extensive knowledge of T cell biology including activation pathways, signaling pathways and antigen-specific driven differentiation to optimization of lead CAR/eTCR T cell therapeutic candidates
Designing and implementing critical studies required to drive hypothesis-driven research
Conceive and develop novel in vitro assays/models to evaluate CAR T/TCR engineered T cell functionality
Identify and present opportunities to develop scientists
Mentoring direct reports to provide guidance for outlining studies required for project advancement
Provide leadership and shape the culture of a functional group
Anticipates the need for contingencies and demonstrates flexibility through development of alternative strategies
Identification and conception of novel strategies for improving T cell function and leading design and characterization activities to enable science-driven decision making
Building constructive relationships across the organization to achieve the goals of the function and the business through leadership roles on cross-functional/divisional teams


Qualifications:


Ph.D. in immunology, immune-oncology or tumor immunology with at least 3 years of successful postdoctoral experience as demonstrated by strong publication record plus at least 5 years of experience in an industry setting or a M.S. with a minimum of 14 years of relevant work experience or B.S. with minimum of 16 years of relevant work experience in T cell immunology
Experience with technologies typically employed to assess T cell functionality including but not limited to MSD, IncuCyte-based assays, multi-parameter flow cytometry for phenotypic characterization of T cells, T cell activation assays, T cell proliferation analysis, imaging technologies
Demonstrates in-depth, scientific-directed, innovative thinking
Self-motivated and focused with project management-oriented thinking; able to work on multiple projects in a matrix environment
Ability to work well as both team member and as individual contributor is essential
Good communication skills for cross-functional interactions as well as upper management interactions; excellent oral presentation skills are critical
Requires strong organizational skills to ensure thorough and timely documentation of experiments, including those of their direct reports, and preparation of data for compiling reports
Experience leading projects through building/leading cross-functional teams
Supervisory experience is required


Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Company: Bristol-Myers Squibb

Req Number: R1522326_EN

Updated: 2020-03-11 00:00:00.000 UTC

Location: Seattle,Washington

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

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