Scientist 1 Antibody Purification

Profile

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

The Discovery Biotherapeutics team at Bristol-Myers Squibb seeks to understand the structure and function of complex molecules such as antibodies and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.

Position Summary:

Our Discovery Biotherapeutics division is seeking a highly motivated and experienced Scientist 1.The successful candidate needs to have demonstrated skills in protein and antibody purification and characterization in the areas of oncology or immuno-oncology drug discovery. This candidate will implement existing automated purification platforms to deliver molecules for multiple programs at varying stages of discovery R&D. Excellent communication, interpersonal and presentation skills demonstrated in a team environment are essential, as well as outstanding analytical and problem-solving abilities.

Responsibilities will include, but are not limited to the following:


Perform automated protein, antibody and bispecific purification and analytical characterization with limited supervision.
Concentrate supernatants via tangential flow filtration, prepare and pack chromatography columns.
Conduct low endotoxin chromatography, including operation of analytical high-pressure chromatography systems and preparative fast performance chromatography systems.
Perform analytical characterization: SDS-PAGE, CE-SDS, endotoxin measurement, protein quantitation assays, analytical SEC.
Prepare formulations: molar concentration, pH adjustment and optimize formulations for protein and antibody stability.
Develop innovative purification and characterization protocols and troubleshoot existing protocols with limited supervision.
Perform inventory management of all purified molecules which includes storing, cataloging, database entry.
Participate on cross-functional teams by performing assigned experiments and offering technical advice at team meetings; share technical expertise with other colleagues; train or provide guidance to other personnel as needed.
Give routine presentations of experimental plans and data in team and department settings.


Requirements :


Ph.D. in a scientific discipline with at least 2 years of relevant work experience, preferred. Bachelor's degree in a scientific discipline with at least 10 years' experience or Master's degree with at least 8 years of relevant work experience.
Hands on experience with complex molecules such as bispecific and multispecific antibodies is desired.
Extensive experience with Cytiva AKTA Avant/Pure and Unicorn software is required.
Experience with affinity, IEX, hydrophobic, mixed-mode and size exclusion chromatography is required.
Hands on experience in mammalian cell culture is a plus.
Independently operate analytical instruments such as spectrophotometers, analytical HPLC, capillary electrophoresis and plate readers.
Must be highly self-motivated, well organized and work effectively as part of a team.
Excellent time management and organizational skills is required.
Strong written and oral communication skills are essential. Includes management of protein inventory and integration with Genedata Biologics, Labmatrix and ELN.
Fundamental knowledge and understanding of drug discovery and antibody discovery process is preferred.


Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Company: Bristol-Myers Squibb

Req Number: R1526295_EN

Updated: 2020-06-12 00:00:00.000 UTC

Location: San Diego,California

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

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