Process Engineer I Process Analytical Technology Development

Profile

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

Job Description:

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

CAR-T cancer therapies are a revolutionary advance in medical treatment, but the success of these new treatment depends upon our ability to develop robust and affordable production methods. As part of our manufacturing development team, we are seeking a highly capable and enthusiastic Process Engineer I to work with a multidisciplinary group of engineers and scientists to support the development of novel Process Analytical Technologies (PAT). The successful candidate will work to develop technologies to provide enhanced process understanding and product control for autologous and allogeneic Cell Therapy products. This role requires direct hands-on experience with cell culture process analytical instrumentation and in-depth method and instrument troubleshooting skills. The candidate will additionally be expected to execute T cell culture experiments using a combination of scale-down models and manufacturing scale bioreactors.

The successful candidate will:


Partner with colleagues in Platform and Technology development teams as well as external suppliers to design, develop and implement innovative on-line/in-line/at-line sensors and process analyzers
Execute feasibility testing of emerging technologies and engage with key stake holders to ensure technology development alignment with Cell Therapy program requirements
Collaborate with internal partners to experimentally determine key CAR-T process and product control attributes, analyze results and draft technical reports to communicate key conclusions
Support PAT equipment and single-use systems integration within Cell Therapy process unit operations
Compile comprehensive data package, operating procedures, and technical documentation to support technology implementation within development and manufacturing organizations
Perform process analytics including flow cytometry


Basic Qualifications:


B.Sc. in Chemical or Biological Engineering with 3-4 years of relevant process analytical experience within the Cell and Gene Therapy or Biologics industry
Hands-on experience with development and operationalization of novel on-line/in-line/at-line sensors and process analyzers
Experience with equipment support and troubleshooting
Demonstrated independence in experimental design, execution, data analysis and troubleshooting
Experience with tissue cell culture, preferably with primary cells


Preferred Qualifications:


Experience with bioreactor cell culture
Experience with cell selection, T cell activation, cell washing, lentiviral transduction, and cryopreservation
Experience with Microsoft Excel, Prism (Graphpad), and statistical programs for data analysis (JMP)
Excellent technical writing and oral communication skills
Driven individual that works well independently and within a multidisciplinary team


Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Company: Bristol-Myers Squibb

Req Number: R1523107_EN

Updated: 2020-03-18 00:00:00.000 UTC

Location: Seattle,Washington

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

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