Principle Scientist Enzymology/Protein Degradation

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At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

At Bristol Myers Squibb we offer an exciting and dynamic environment to apply your scientific expertise to improving the lives of patients while providing a supportive culture committed to growing your career.

As a Principal Scientist within Leads Discovery and Optimization at **MEMBERS ONLY**SIGN UP NOW***., the successful candidate will be trained and skilled in enzymology as it relates to discovery of novel enzyme inhibitors. They will be responsible for leading a team of scientists to drive the design, execution, and interpretation of assays probing enzyme activity and important mechanistic and kinetic questions in support of our drug discovery programs across therapeutic areas. The individual will also support a robust and growing pipeline of drug discovery targets directed toward the exciting new modality of protein degraders as we look to expand our approved drugs in this class as well as our capabilities. The ideal candidate will be an enthusiastic, self-starter with in-depth knowledge and a demonstrated publication record in relation to enzyme kinetics, mechanisms of inhibition and enzyme assay platforms. As a member of a dynamic organization, the person will have the opportunity to collaborate closely with existing team members as well as actively collaborate with chemists and biologists across our therapeutic portfolio teams in order to support and provide insight for a robust and diverse enzyme inhibitor drug discovery portfolio.

Qualifications:


PhD, plus relevant postdoctoral work and 10 years of industry experience in enzymology, enzyme kinetic and drug discovery research


Duties/Responsibilities:


Design and execution of de novo assays to explore kinetics and mechanism of action of enzyme inhibitors
Tangible experience with cutting-edge assay design techniques for interpreting classes of enzyme inhibitors
A demonstrated ability to innovate and employ new approaches and technologies in enabling difficult drug discovery targets
Familiarity with common assay platforms and approaches such as stopped flow and mass spectrometry- experience with fluorescence/luminescence-based target binding assays and or proximity-based assays is helpful.
Experience in drug discovery as it relates to targeted protein degradation and E3 ubiquitin ligase recruitment is a plus
Highly skilled in troubleshooting experimental design with the ability to effectively organize, analyze and depict data using common software packages (e.g. GraphPad PRISM, EXCEL, SpotFire, SigmaPlot)
Strong inter-personal and communication skills
Experience leading/managing others
Ability to learn quickly and work closely with others in a team environment


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Company: Bristol-Myers Squibb

Req Number: R1526786_EN

Updated: 2020-06-22 00:00:00.000 UTC

Location: Princeton,New Jersey

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

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