Principal Scientist Assay Development MoCR/ICF

Profile

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

Summary: The Biochemistry, Cell Biology and Molecular Pharmacology group in Cambridge is dedicated to working closely with chemistry colleagues in discovering novel small molecule therapeutics for immunological & neurological diseases and overcoming cancer resistance. Our primary role is to develop and apply robust biochemical and cell biology tools that enable small molecule drug discovery. These critical components of the drug discovery process provide in vitro data that guide early discovery and underpin their performance in preclinical disease settings. The data generated ultimately allows selection of drug candidates and forms an essential element in IND filings with the FDA for clinical development.

Description: We seek a highly motivated and innovative leader to build and lead a laboratory group located in Cambridge, MA. The candidate will lead a research team that partners with and is integral to Oncology Biology, Translational Medicine, and Molecular Discovery Technology at Cambridge with a mission to discover and develop innovative Oncology therapeutics. This group will develop assays that enable drug discovery teams to identify and triage hits and optimize lead chemical matter. This leader will also represent the core capabilities in our New Jersey facility. In that capacity they will bring high throughput assays from NJ to bear on local projects or transfer assays from Cambridge to NJ, as appropriate, and will manage these needs across the oncology portfolio.

The successful candidate will have:


Deep knowledge of cell signaling in cancer biology
Strong track record of developing and validating biochemical and cellular assays
Hands on knowledge of automated platforms used for hit identification and lead optimization
Proficiency in designing 384 & 1536 well assays and be adept with robotics and lab automation
Broad knowledge in compound screening strategy (essential)
Hands-on experience w multiple cell-based and biochemical assay technologies such as flow cytometry, HTRF, qPCR, etc
Experience with identifying and innovating new technologies that bolster discovery
Highly collaborative spirit for working across R&D and an insatiable curiosity
Analytical skills to generate and interpret complex data and mechanistic data packages
Aptitude to generate new hypotheses and design experiments that test them
Ability to manage projects across functional lines and geographic locations
Strong written & verbal communication skills for presenting data and ideas to multiple stakeholders across disciplines
Strong scientific leadership both at the bench and in data analysis
Management skills to direct a team of junior scientists in effective and efficient operation


Qualifications:


PHD in cell biology, biochemistry or equivalent
8 or more years of recent experience in oncology drug discovery
Demonstrated expertise in biochemical & cellular assay design & implementation
Deep experience with utilizing automated platforms


Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Company: Bristol-Myers Squibb

Req Number: R1524807_EN

Updated: 2020-05-18 00:00:00.000 UTC

Location: Cambridge,Massachusetts

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

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